Advanced Engineering

SGI has pioneered rapid, complex, precision engineering

Integration is innovation

Integrating and continually optimizing all steps of the Design-Build-Test cycle increases the speed and efficiency of engineering genomes for specific applications. SGI has built the leading set of capabilities, tools, know-how and intellectual property in the fields of synthetic biology and synthetic genomics. Our world-class team of scientists in La Jolla, CA focus on utilizing the “right tool” for the desired outcome at every step of the process.

Design

Learning from and inspired by nature

SGI is a world leader in bioinformatics. Every product, solution and innovation we create starts with data. We have sequenced an annotated thousands of genomes across a vast array of different organisms from all parts of the globe. Our proprietary Archetype^® platform puts analysis and design tools in the hands of researchers, distilling complex genomic information and phenotypic predictions into actionable information. Understanding nature’s design rules, how living organisms have evolved, and how they function allows our team to transition smoothly from in silico design to DNA synthesis and assembly.

Build

The right tool for the right application

DNA synthesis and assembly

Acceleration of the design-build-test cycle

Array-based synthesis platform
Versatile and robust assembly and cloning
Scalable error-free DNA synthesis and assembly
Pathway and genome synthesis capabilities
BioXP moves advanced engineering technologies on the benchtop

Precision and complex genome engineering

Leveraging nature, enabling life

“Top down” — High efficiency, precise editing, insertion, deletion of virtually any type in existing genomes
“Bottom up” — Complete de novo synthesis of fully synthetic genomes of any design

Test

Novel approaches to evaluation

The SGI team is comprised of world-renowned experts across viral, microbial, algal, yeast and mammalian cell engineering. We have engineered over one billion base pairs since our inception. The deep knowledge across this broad collection of systems has enabled our team to design novel assays and approaches to testing the engineering changes to ensure a desired outcome. Continuous improvement and innovation in the “test” portion of the cycle is critical to achieving speed and accuracy across our programs.